1. Organ-on-a-chip Systems & Organoids

Applying the principles of tissue engineering, we establish microphysiological systems (OoCs), by using microfluidic devices, functional biomaterials, human stem cells and clinical samples, and appropriate environmental cues (both biophysical and biochemical), to replicate healthy or diseased human tissues and organs, particularly those of the musculoskeletal system. We also have a strong interest in deriving miniaturized tissue/organ models using organoid technology.

2. Advanced nanobiomaterials and biofacbriction for modulating stem cell behaviors

We employ both inorganic (bioceramics and inorganic nanoparticles) and organic materials (photo-crosslinkable hydrogels and delivery systems), as scaffolds or biomolecule delivery systems, to modulate stem cell behaviors. Our innovations in materials synthesis are clinical need-driven, and we emphasize the molecular mechanisms underlying biomaterials performance and regenerative outcomes. We also utilize 3D/4D (bio)printing to fabricate intricate tissue constructs for functional restoration of diseased tissues and organs.

3. Stem cells for neuromusculoskeletal regeneration

We use human mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), among other cell types, to repair and regenerate diseased tissues. We are particularly interested in harnessing the intrinsic regenerative potential of human stem cells. Our main targeted applications are in neuromusculoskeletal regeneration.

4. Drug Testing & Personalized Medicine

We employ advanced 3D culture platforms, such as OoCs and organoids, to generate disease models with high physiological and clinical relevance for studying disease mechanisms and evaluating the safety and efficacy of potential drugs and regenerative therapies. Using patient-specific cells (e.g., iPSCs from specific donors), we generate “patient-on-a-chip” and personalized organoids for developing precision medicine. We are particularly interested in using OoC applications to elucidate nanotechnology—biology interfaces.